James M. Brimson, Ph.D
Researcher, Lecturer, Principle Investigator.

Thitilertdecha, Premrutai, and James Michael Brimson. "CT1812, a Small Molecule Sigma-2 Receptor Antagonist for Alzheimer’s Disease Treatment: A Systematic Review of Available Clinical Data." Journal of Alzheimer's Disease101.s1 (2024): S115-S128.

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Prasanth, Mani Iyer, Dhammika Leshan Wannigama, Angela Michelle Reiersen, Premrutai Thitilertdecha, Anchalee Prasansuklab, Tewin Tencomnao, Sirikalaya Brimson, and James Michael Brimson. "A systematic review and meta-analysis, investigating dose and time of fluvoxamine treatment efficacy for COVID-19 clinical deterioration, death, and Long-COVID complications." Scientific Reports 14, no. 1 (2024): 13462.

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Prasanth, Mani Iyer, Bhagavathi Sundaram Sivamaruthi, Clerance Su Yee Cheong, Kanika Verma, Tewin Tencomnao, James Michael Brimson, and Anchalee Prasansuklab. "Role of Epigenetic Modulation in Neurodegenerative Diseases: Implications of Phytochemical Interventions." Antioxidants 13, no. 5 (2024): 606.

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​Prasanth, Mani Iyer, Kanika Verma, Sirikalaya Brimson, Tewin Tencomnao, and James Michael Brimson. "Simple ammonium salt and sigma-1 receptor ligand dipentylammonium provides neuroprotective effects in cell culture and Caenorhabditis elegans models of Alzheimer's disease." Biomedicine & Pharmacotherapy 173 (2024): 116455.

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​Wannigama, Dhammika Leshan, Cameron Hurst, Phatthranit Phattharapornjaroen, Parichart Hongsing, Natchalaikorn Sirichumroonwit, Kanokpoj Chanpiwat, Ali Hosseini Rad SM et al. "Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trial." EClinicalMedicine 70 (2024).

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Malar, Dicson Sheeja, Kanika Verma, Mani Iyer Prasanth, Tewin Tencomnao, and James Michael Brimson. "Network analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimer’s, and diabetes." Scientific Reports 14, no. 1 (2024): 4328

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Malar, Dicson S., Premrutai Thitilertdecha, Kanokphorn S. Ruckvongacheep, Sirikalaya Brimson, Tewin Tencomnao, and James M. Brimson. "Targeting sigma receptors for the treatment of neurodegenerative and neurodevelopmental disorders." CNS drugs 37, no. 5 (2023): 399-440.

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Prasanth, Mani Iyer, James Michael Brimson, and Tewin Tencomnao. "Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2." Expert Opinion on Therapeutic Targets 27.4-5 (2023): 263-267.

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​Chomchoei, C., J. M. Brimson, and S. Brimson. "Repurposing fluoxetine to treat lymphocytic leukaemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction." Expert Opinion on Therapeutic Targets (2023).

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Malar, D. S., Prasanth, M. I., Brimson, J. M., Verma, K., Prasansuklab, A., & Tencomnao, T. Neuroprotective effect of Hibiscus sabdariffa extract against high glucose-induced toxicity in Neuro-2a cells and Caenorhabditis elegans. Nutrition and Healthy Aging, (Preprint), 1-25

Rakkhitawatthana V, Sillapachaiyaporn C, Nilkhet S, Brimson JM, Tencomnao T. Effect of Thai medicinal plants Acanthus ebracteatus Vahl. Carthamus tinctorius L. and Streblus asper Lour. on neurite outgrowth activity in Neuro-2A cells. Journal of Associated Medical Sciences. 2023;56(1):71-84.

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Rakkhittawattana, V., Panichayupakaranant, P., Prasanth, M. I., Brimson, J. M., & Tencomnao, T. (2022). Rhinacanthin-C but Not-D Extracted from Rhinacanthus nasutus (L.) Kurz Offers Neuroprotection via ERK, CHOP, and LC3B Pathways. Pharmaceuticals, 15(5), 627.

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Kabra, Dr, Ruchika Garg, James Michael Brimson, Jelena Zivkovic, Muhammad Ayaz, Asif Nawaz, Syed Shams Ul Hassan, and Simona Gabriela Bungau. "Mechanistic insights into the role of plant polyphenols and their nanoformulations in the management of depression." Frontiers in Pharmacology: 4731.

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Brimson, James M. et al. ‘Bacopa Monnieri Protects Neuronal Cell Line and Caenorhabditis Elegans Models of Alzheimer’s Disease through Sigma-1 Receptor Antagonist Sensitive and Antioxidant Pathways’. 1 Jan. 2022 : 1 – 24.

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Prasanth, M. I., Malar, D. S., Brimson, J. M., Verma, K., Tonsomboon, A., Plaingam, W., & Tencomnao, T. DAF-16 and SKN-1 mediate Anti-aging and Neuroprotective efficacies of “thai ginseng” Kaempferia parviflora Rhizome extract in Caenorhabditis elegans. Nutrition and Healthy Aging, (Preprint), 1-16.

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Brimson, J. M., Prasanth, M. I., Malar, D. S., Thitilertdecha, P., Kabra, A., Tencomnao, T., & Prasansuklab, A. (2021). Plant Polyphenols for Aging Health: Implication from Their Autophagy Modulating Properties in Age-Associated Diseases. Pharmaceuticals, 14(10), 982.

 

Prasanth, M. I., Tencomnao, T., & Brimson, J. M. (2021). The role of the sigma-1 receptor in neuroprotection: Comment on Nrf-2 as a therapeutic target in ischemic stroke. Expert opinion on therapeutic targets, 25(7), 613-614.

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Brimson, J. M., Prasanth, M. I., Malar, D. S., Brimson, S., Thitilertdecha, P., & Tencomnao, T. (2021). Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: the possible role of the sigma-1 receptor and autophagy. Expert Opinion on Therapeutic Targets, 25(6), 435-449.

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Brimson, J. M., Brimson, S., Prasanth, M. I., Thitilertdecha, P., Malar, D. S., & Tencomnao, T. (2021). The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data. Scientific reports, 11(1), 1-11.

 

Prasanth, M. I., Brimson, J. M., Sheeja Malar, D., Prasansuklab, A., & Tencomnao, T. (2021). Streblus asper Lour. exerts MAPK and SKN-1 mediated anti-aging, anti-photoaging activities and imparts neuroprotection by ameliorating Aβ in Caenorhabditis elegans. Nutrition and Healthy Aging, 6(3), 211-227.

Brimson, J. M., Prasanth, M. I., Isidoro, C., Sukprasansap, M., & Tencomnao, T. (2021). Cleistocalyx nervosum var. paniala seed extracts exhibit sigma-1 antagonist sensitive neuroprotective effects in PC12 cells and protects C. elegans from stress via the SKN-1/NRF-2 pathway. Nutrition and Healthy Aging, 6(2), 131-146.

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Sulistiyani, E., Brimson, J. M., Chansaenroj, A., Sariya, L., Urkasemsin, G., Oonsiri, S., ... & Ferreira, J. N. (2021). Epigallocatechin-3-Gallate Protects Pro-Acinar Epithelia Against Salivary Gland Radiation Injury. International journal of molecular sciences, 22(6), 3162.

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Brimson, J.M.; Prasanth, M.I.; Malar, D.S.; Brimson, S.; Tencomnao, T. Rhinacanthus nasutus “Tea” Infusions and the Medicinal Benefits of the Constituent Phytochemicals. Nutrients, 2020, 12, 3776.

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Brimson, J. M., Brimson, S., Chomchoei, C., & Tencomnao, T. (2020). Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain. Expert Opinion on Therapeutic Targets, 24(10), 1009-1028.

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Malar, D. S., Prasanth, M. I., Brimson, J. M., Sharika, R., Sivamaruthi, B. S., Chaiyasut, C., & Tencomnao, T. (2020). Neuroprotective properties of green tea (Camellia sinensis) in Parkinson’s disease: a review. Molecules, 25(17), 3926.

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Brimson, J. M., et al. "Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression." Scientific Reports 10.1 (2020): 9251-9251.

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Brimson, James Michael, Mani Iyer Prasanth, Waluga Plaingam, and Tewin Tencomnao. "Bacopa monnieri (L.) wettst. extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans." Journal of traditional and complementary medicine 10, no. 5 (2020): 460-470.

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Prasansuklab, Anchalee, James M. Brimson, and Tewin Tencomnao. "Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect." Journal of Traditional and Complementary Medicine (2020).

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Prasanth, Mani Iyer, et al. "Antiaging, Stress Resistance, and Neuroprotective Efficacies of Cleistocalyx nervosum var. paniala Fruit Extracts Using Caenorhabditis elegans Model." Oxidative Medicine and Cellular Longevity 2019 (2019).

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Brimson, Sirikalaya, Yaneenart Suwanwong, and James M. Brimson. "Nutritional anemia predominant form of anemia in educated young Thai women." Ethnicity & Health 24, no. 4 (2019): 405-414.

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Brimson, James M., Nattawat Onlamoon, Tewin Tencomnao, and Premrutai Thitilertdecha. "Clerodendrum petasites S. Moore: The therapeutic potential of phytochemicals, hispidulin, vanillic acid, verbascoside, and apigenin." Biomedicine & Pharmacotherapy 118 (2019): 109319.

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Brimson, J.M., Safrany, S.T., Qassam, H., Tencomnaow, T. "Dipentylammonium Binds to the Sigma-1 Receptor and Protects Against Glutamate Toxicity, Attenuates Dopamine Toxicity and Potentiates Neurite Outgrowth in Various Cultured Cell Lines" Neurotox Res (2018) 34: 263.

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Safrany, S. T., and J. M. Brimson. "Are fluoxetine’s effects due to sigma-1 receptor agonism?." Pharmacological research 113 (2016): 707-708.

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Cao Shuqin, James M. Brimson, and Tewin Tencomnao. "Comparative antioxidant activity and potential neuroprotective of Zingiber officinale Roscoe extracts collected from Thailand and Malaysia against glutamate-induced oxidative neurotoxicity." Journal of International Society of Antioxidants in Nutrition & Health 3, no. 1 (2016).

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Adewale, O. O., J. M. Brimson, O. A. Odunola, M. A. Gbadegesin, S. E. Owumi, C. Isidoro, and T. Tencomnao. "The Potential for Plant Derivatives against Acrylamide Neurotoxicity." Phytotherapy Research 29, no. 7 (2015): 978-985.

Brimson, James M., and Tewin Tencomnao. "Medicinal herbs and antioxidants: potential of Rhinacanthus nasutus for disease treatment?." Phytochemistry reviews 13, no. 3 (2014): 643-651.

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Brimson, James M., and Tewin Tencomnao. "Rhinacanthus nasutus protects cultured neuronal cells against hypoxia induced cell death." Molecules 16, no. 8 (2011): 6322-6338.

Brimson, James M., C. A. Brown, and Stephen T. Safrany. "Antagonists show GTP‐sensitive high‐affinity binding to the sigma‐1 receptor." British journal of pharmacology 164, no. 2b (2011): 772-780.
 

Brimson, James M., Sirikalaya J. Brimson, Christopher A. Brimson, Varaporn Rakkhitawatthana, and Tewin Tencomnao. "Rhinacanthus nasutus extracts prevent glutamate and amyloid-β neurotoxicity in HT-22 mouse hippocampal cells: possible active compounds include lupeol, stigmasterol and β-sitosterol." International journal of molecular sciences 13, no. 4 (2012): 5074-5097.

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